The protective effect of celery ethanol extract on oxidative stress in chronic kidney disease rat model

BackgroundChronic kidney disease (CKD) is a serious health problem in which oxidative stress plays an important role. Oxidative imbalance of reactive oxygen species (ROS) production and antioxidant defense, where antioxidants have the potential to inhibit CKD progression. Celery contains several substances that effect. This study aimed evaluate administration celery ethanol extract prevention progressive damage caused by male rats. MethodsTwenty Sprague-Dawley rats were randomly divided into 5 groups: sham operation (SO, n=4), subtotal nephrectomy (SN, SN+celery 200 mg/kg BW (SN+S1, 250 (SN+S2, 300 (SN+S3, n=4). The was given for 14 days before induction 21 after rat model. Serum creatinine, malondialdehyde (MDA), superoxide dismutase (SOD) glutathione (GSH) examined this study. Data analyzed One way ANOVA followed LSD test MDA, SOD, Kruskal Wallis GSH. ResultsThere significant between-group differences serum MDA (p<0.05), but not GSH (p>0.05). at most effective preventing increase decrease SOD ConclusionCelery has prevent